Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | THRA | P10827 | 9/20 | 0.40 |
| ▸ | THRB | P10828 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202189 | 0.89 | HTR2B (0.54) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL9208221 | 0.88 | HTR2A (0.44) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL20970887 | 0.84 | TP53 (0.46) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL9211145 | 0.83 | HTR2B (0.50) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL4796985 | 0.83 | HTR2B (0.63) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL9204210 | 0.81 | LMNA (0.46) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL31134129 | 0.81 | HTR2A (0.50) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL9205685 | 0.81 | HTR2A (0.45) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL9203858 | 0.79 | THRA (0.43) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL38657787 | 0.74 | HTR1D (0.61) | HTR1DHTR1BSRCMAPTTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |