Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208724 | 0.80 | ADORA3 (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9209339 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9217209 | 0.75 | ADORA3 (0.45) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9216799 | 0.74 | KDM4E (0.42) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9217137 | 0.69 | ADORA3 (0.43) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL10845246 | 0.68 | PDE4A (0.40) | MAPK1 | |
| SCHEMBL11754694 | 0.66 | ELANE (0.48) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL15560128 | 0.65 | ELANE (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL38660692 | 0.65 | MEN1 (0.76) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9209360 | 0.65 | ADORA3 (0.43) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476544-B1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5192768-A | Antiinflammatory, hepatic insufficiency | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0476544-A1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |