Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RORA | P35398 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | RORB | Q92753 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217137 | 0.85 | ADORA3 (0.43) | ADORA3PGRKDM4EGAARORA | |
| SCHEMBL9209360 | 0.85 | ADORA3 (0.43) | ADORA3PGRKDM4EGAARORA | |
| SCHEMBL9208724 | 0.81 | ADORA3 (0.47) | ADORA3PGRKDM4EGAARORA | |
| SCHEMBL9213745 | 0.75 | KDM4E (0.47) | ADORA3PGRKDM4EGAAPOLB | |
| SCHEMBL9198164 | 0.65 | PDE4A (0.58) | ADORA3PGRKDM4EGAARORA | |
| SCHEMBL1896422 | 0.65 | ALDH1A1 (0.43) | ADORA3KDM4ETSHRNPC1ALDH1A1 | |
| SCHEMBL27203707 | 0.64 | HTR3A (0.42) | KDM4EHSD17B10AURKASYKAURKB | |
| SCHEMBL14374207 | 0.63 | MAT2A (0.43) | PGRKDM4ERORARORCRORB | |
| SCHEMBL9213798 | 0.63 | PGR (0.49) | ADORA3PGRKDM4EGAARORA | |
| SCHEMBL9851037 | 0.63 | LMNA (0.50) | ADORA3PGRKDM4EGAARORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476544-B1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5192768-A | Antiinflammatory, hepatic insufficiency | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0476544-A1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |