Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | RORA | P35398 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | RORB | Q92753 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209339 | 0.88 | KDM4E (0.44) | KDM4EMAPK1NPSR1MEN1KMT2A | |
| SCHEMBL9213745 | 0.74 | KDM4E (0.47) | KDM4EMAPK1NPSR1MEN1KMT2A | |
| SCHEMBL9217657 | 0.73 | UTS2R (0.46) | KDM4ENPSR1ALDH1A1HPGDUTS2R | |
| SCHEMBL9213798 | 0.72 | PGR (0.49) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL15560128 | 0.62 | ELANE (0.47) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9218908 | 0.61 | PLK1 (0.46) | KDM4ENPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9208527 | 0.61 | ADORA3 (0.53) | KDM4EMAPK1ALDH1A1HPGDUSP2 | |
| SCHEMBL9208724 | 0.60 | ADORA3 (0.47) | KDM4EMAPK1NPSR1MEN1KMT2A | |
| SCHEMBL29441519 | 0.60 | ADORA2A (0.41) | MAPK1 | |
| SCHEMBL1061988 | 0.60 | PGR (0.50) | KDM4EMAPK1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476544-B1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5192768-A | Antiinflammatory, hepatic insufficiency | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0476544-A1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |