Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050683 | 0.90 | MAPT (0.51) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL6050674 | 0.78 | PRKCZ (0.54) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL6050689 | 0.77 | PTGS2 (0.58) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL6050666 | 0.77 | PTGS2 (0.58) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL9214649 | 0.77 | PRKCZ (0.53) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL6050717 | 0.76 | PRKCZ (0.55) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL20015818 | 0.73 | MAPT (0.59) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL9203822 | 0.73 | MAPT (0.46) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL5237356 | 0.71 | MAPT (0.56) | MAPTKDM4ENPC1RAB9APRKCZ | |
| SCHEMBL28228755 | 0.70 | PRKCZ (0.61) | MAPTKDM4ENPC1RAB9APRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679157-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994015932-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1994-07-21 | — | — | WO | disclosed |