Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9208073 | 0.90 | PRMT5 (0.40) | PRMT5WDR77SIGMAR1 | |
| SCHEMBL9214969 | 0.89 | PRMT5 (0.43) | PRMT5WDR77ABCB1SIGMAR1 | |
| SCHEMBL9213097 | 0.87 | PDE4B (0.43) | PRMT5WDR77ABCB1 | |
| SCHEMBL9214560 | 0.83 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL9214376 | 0.80 | KDM4E (0.40) | PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9214826 | 0.80 | PRMT5 (0.39) | PRMT5WDR77SIGMAR1 | |
| SCHEMBL9215026 | 0.78 | MEN1 (0.43) | ABCB1SIGMAR1 | |
| SCHEMBL9212338 | 0.78 | RAB9A (0.40) | PRMT5WDR77SIGMAR1 | |
| SCHEMBL9213257 | 0.78 | PRMT5 (0.42) | PRMT5WDR77 | |
| SCHEMBL9739331 | 0.76 | MEN1 (0.47) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |