Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214221 | 0.92 | TDP1 (0.58) | PTGDR2TDP1TSHRPOLBTP53 | |
| SCHEMBL9213387 | 0.89 | TDP1 (0.55) | PTGDR2TDP1TSHRPOLBTP53 | |
| SCHEMBL9209426 | 0.89 | TDP1 (0.62) | PTGDR2TDP1TSHRPOLBTP53 | |
| SCHEMBL9217624 | 0.86 | PTGDR2 (0.69) | PTGDR2MAPT | |
| SCHEMBL9212883 | 0.86 | PTGDR2 (0.57) | PTGDR2TP53MAPTKDM4E | |
| SCHEMBL9218825 | 0.84 | TDP1 (0.52) | PTGDR2TDP1TSHRPOLBMAPT | |
| SCHEMBL21467267 | 0.84 | POLB (0.57) | POLBTP53MAPTTHRBKDM4E | |
| SCHEMBL14419478 | 0.84 | PTGDR2 (0.57) | PTGDR2TDP1TSHRPOLBMAPT | |
| SCHEMBL30070794 | 0.84 | POLB (0.57) | POLBTP53MAPTTHRBKDM4E | |
| SCHEMBL14419292 | 0.83 | PTGDR2 (0.56) | PTGDR2TDP1TSHRPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |