Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211726 | 0.87 | EPHX2 (0.49) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| Hydrochloric Acid SCHEMBL9218721 | 0.86 | EPHX2 (0.48) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL9214502 | 0.82 | KMT2A (0.61) | EPHX2CYP2C9CYP2C19LMNAPLOD2 | |
| SCHEMBL9212192 | 0.82 | CFTR (0.44) | EPHX2CYP2C9CYP2C19LMNAPLOD2 | |
| SCHEMBL9502986 | 0.81 | THRB (0.45) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| Hydrochloric Acid SCHEMBL9211784 | 0.81 | CFTR (0.43) | EPHX2CYP2C9CYP2C19LMNAPLOD2 | |
| SCHEMBL9211853 | 0.80 | EPHX2 (0.63) | EPHX2LMNAMEN1NPC1RAB9A | |
| SCHEMBL9211594 | 0.79 | KEAP1 (0.52) | EPHX2CYP2C9CYP2C19PLOD2MEN1 | |
| SCHEMBL5947875 | 0.78 | EPHX2 (1.00) | EPHX2CYP2C9CYP2C19LMNAHPGD | |
| SCHEMBL9603448 | 0.78 | EPHX2 (0.71) | EPHX2CYP2C9CYP2C19LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | claimed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | claimed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |