Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 6/20 | 0.49 |
| ▸ | HTR1B | P28222 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213173 | 0.89 | HTR1D (0.47) | HTR1DHTR1BHTR1ASLC6A4MAPT | |
| SCHEMBL9206755 | 0.87 | HTR1D (0.43) | HTR1DHTR1BHTR1ASLC6A4MAPT | |
| SCHEMBL9209371 | 0.87 | HTR1D (0.52) | HTR1DHTR1BHTR1ASLC6A4 | |
| SCHEMBL9206604 | 0.84 | HTR1A (0.55) | HTR1ASLC6A4MAPTMEN1LMNA | |
| SCHEMBL9215781 | 0.83 | HTR1D (0.48) | HTR1DHTR1BHTR1ASLC6A4MAPT | |
| SCHEMBL9216571 | 0.79 | PDE4D (0.49) | HTR1DHTR1BHTR1ASLC6A4PDE4D | |
| SCHEMBL9213471 | 0.79 | HTR1A (0.61) | HTR1ASLC6A4 | |
| SCHEMBL9215340 | 0.78 | HTR1A (0.47) | HTR1DHTR1BHTR1ASLC6A4MAPT | |
| Hydrochloric Acid SCHEMBL9740012 | 0.78 | PDE4D (0.48) | HTR1DHTR1BHTR1ASLC6A4PDE4D | |
| Hydrochloric Acid SCHEMBL9212006 | 0.77 | HTR1A (0.46) | HTR1DHTR1BHTR1ASLC6A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |