Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.47 |
| ▸ | HTR1B | P28222 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215781 | 0.94 | HTR1D (0.48) | HTR1DHTR1BSLC6A4TRPM8KDM4E | |
| SCHEMBL9215424 | 0.89 | HTR1D (0.49) | HTR1DHTR1BSLC6A4TRPM8KDM4E | |
| Water SCHEMBL9739470 | 0.78 | HTR1A (0.45) | HTR1DHTR1BSLC6A4HTR1AHTR2A | |
| SCHEMBL9209371 | 0.77 | HTR1D (0.52) | HTR1DHTR1BSLC6A4HTR1A | |
| SCHEMBL9215340 | 0.77 | HTR1A (0.47) | HTR1DHTR1BSLC6A4MAPTHTR1A | |
| Hydrochloric Acid SCHEMBL9212006 | 0.76 | HTR1A (0.46) | HTR1DHTR1BSLC6A4MAPTHTR1A | |
| SCHEMBL9206755 | 0.76 | HTR1D (0.43) | HTR1DHTR1BSLC6A4MAPTHTR1A | |
| SCHEMBL9624939 | 0.75 | HTR1D (0.54) | HTR1DSLC6A4TRPM8KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9213791 | 0.74 | ACHE (0.37) | ACHE | |
| SCHEMBL9210499 | 0.74 | HTR1A (0.59) | SLC6A4ADRA1AHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |