Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215429 | 0.86 | HTR1A (0.47) | HTR1AMEN1MAPTKMT2ASLC6A4 | |
| SCHEMBL9206755 | 0.85 | HTR1D (0.43) | HTR1AMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9213471 | 0.84 | HTR1A (0.61) | HTR1ASLC6A2SLC6A4SLC6A3ADRA2A | |
| SCHEMBL9215424 | 0.84 | HTR1D (0.49) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9214068 | 0.81 | HTR1D (0.42) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9215781 | 0.79 | HTR1D (0.48) | HTR1AMAPTSLC6A4ADRA1AHTR2A | |
| SCHEMBL9216672 | 0.79 | CHRNB2 (0.47) | MEN1KMT2A | |
| SCHEMBL9210499 | 0.78 | HTR1A (0.59) | HTR1ASLC6A2SLC6A4SLC6A3ADRA2A | |
| SCHEMBL9624897 | 0.78 | HTR1A (0.52) | HTR1AMEN1LMNAMAPTKMT2A | |
| SCHEMBL9214106 | 0.78 | HTR1A (0.61) | HTR1ASLC6A2SLC6A4SLC6A3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |