Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214452 | 0.97 | GRM5 (0.40) | GRM5HRH3CCR2KCNH2CHRNB2 | |
| Hydrochloric Acid SCHEMBL9214335 | 0.96 | GRM5 (0.39) | GRM5HRH3CCR2KCNH2CHRNB2 | |
| SCHEMBL9213488 | 0.87 | NAMPT (0.39) | HRH3CCR2KCNH2CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL9740467 | 0.87 | NAMPT (0.38) | HRH3CCR2KCNH2CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL9208814 | 0.85 | CHRNB4 (0.44) | GRM5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9213603 | 0.85 | GRM5 (0.38) | GRM5CCR2KCNH2CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL9215725 | 0.85 | GRM5 (0.38) | GRM5CCR2KCNH2CHRNB2CHRNB4 | |
| SCHEMBL9216662 | 0.84 | HRH3 (0.43) | HRH3CCR2KCNH2CCR5 | |
| SCHEMBL9213007 | 0.83 | GRM5 (0.38) | GRM5HRH3 | |
| SCHEMBL9217159 | 0.83 | ACHE (0.44) | GRM5CHRNB2CHRNA4KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |