Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9216230 | 0.98 | GRM5 (0.37) | GRM5HRH3HSD11B1ACHEDRD2 | |
| SCHEMBL9206331 | 0.91 | HSD11B1 (0.38) | HSD11B1ACHEDRD2SIGMAR1HTR2A | |
| SCHEMBL9739700 | 0.84 | GRM5 (0.41) | GRM5HRH3ACHEDRD4SIGMAR1 | |
| SCHEMBL9214452 | 0.84 | GRM5 (0.40) | GRM5HRH3 | |
| SCHEMBL9210283 | 0.84 | SIGMAR1 (0.42) | HRH3HSD11B1SIGMAR1GRIN2BGRIN1 | |
| SCHEMBL9215804 | 0.83 | GRM5 (0.39) | GRM5HRH3 | |
| Hydrochloric Acid SCHEMBL9214335 | 0.83 | GRM5 (0.39) | GRM5HRH3 | |
| Hydrochloric Acid SCHEMBL9216937 | 0.80 | SIGMAR1 (0.39) | HRH3HSD11B1SIGMAR1GRIN2BGRIN1 | |
| SCHEMBL9207074 | 0.79 | GRM5 (0.42) | GRM5HRH3SIGMAR1 | |
| SCHEMBL9217159 | 0.79 | ACHE (0.44) | GRM5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |