Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207550 | 0.91 | HCN4 (0.47) | MEN1KMT2AHCRTR1HCRTR2MAPT | |
| Hydrochloric Acid SCHEMBL9740428 | 0.91 | CYP3A4 (0.47) | MEN1KMT2AHCRTR1HCRTR2MAPT | |
| Hydrochloric Acid SCHEMBL9740420 | 0.88 | CYP3A4 (0.47) | HCRTR1HCRTR2MAPTHCN4 | |
| Hydrochloric Acid SCHEMBL9742044 | 0.84 | HTT (0.51) | MEN1KMT2APOLBMAOAMAOB | |
| Hydrochloric Acid SCHEMBL9740435 | 0.84 | CYP3A4 (0.47) | MEN1KMT2AHCRTR1HCRTR2MAPT | |
| SCHEMBL9740561 | 0.83 | CHRNB2 (0.49) | MEN1KMT2ALTA4HMAPTHCN4 | |
| SCHEMBL9740052 | 0.83 | MAOA (0.47) | MEN1KMT2APOLBMCHR1MAOA | |
| SCHEMBL9739498 | 0.82 | ABCB1 (0.51) | MEN1KMT2APOLBMAPTHCN4 | |
| Hydrochloric Acid SCHEMBL9739064 | 0.82 | CHRNB2 (0.48) | MEN1KMT2AMAPTHCN4 | |
| Hydrochloric Acid SCHEMBL9739977 | 0.82 | MAOA (0.46) | MEN1KMT2APOLBMCHR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |