Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217641 | 1.00 | MAPK1 (0.39) | MAPK1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL9212010 | 0.96 | MAPK1 (0.42) | MAPK1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL9216674 | 0.92 | SLC6A2 (0.36) | SMN1; SMN2LMNATSHRHTTNAMPT | |
| SCHEMBL9211128 | 0.92 | TBXAS1 (0.40) | SMN1; SMN2LMNATSHRHTTNAMPT | |
| SCHEMBL9213166 | 0.92 | KDM4E (0.41) | SMN1; SMN2LMNATSHRHTTCNR1 | |
| SCHEMBL9220380 | 0.92 | KDM4E (0.41) | SMN1; SMN2LMNATSHRHTTCNR1 | |
| SCHEMBL9211118 | 0.92 | TBXAS1 (0.40) | SMN1; SMN2LMNATSHRHTTNAMPT | |
| SCHEMBL9212826 | 0.91 | MAPK1 (0.38) | MAPK1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL9212029 | 0.91 | ALDH1A1 (0.43) | SMN1; SMN2LMNATSHRHTTNAMPT | |
| SCHEMBL9216984 | 0.91 | ALDH1A1 (0.43) | SMN1; SMN2LMNATSHRHTTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510028-B1 | THIOFORMAMIDE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1995-03-15 | — | — | EP | claimed |
| US-5364853-A | Treatment of disorders associated with vascular, respiratory, gastrointestinal tract, urinary bladder or uterus smooth muscle contraction | RHONE-POULENC RORER LIMITED (GB) | 1994-11-15 | — | — | US | claimed |
| EP-0510028-B1 | THIOFORMAMIDE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1995-03-15 | — | — | EP | disclosed |
| US-5364853-A | Treatment of disorders associated with vascular, respiratory, gastrointestinal tract, urinary bladder or uterus smooth muscle contraction | RHONE-POULENC RORER LIMITED (GB) | 1994-11-15 | — | — | US | disclosed |
| EP-0510028-A1 | THIOFORMAMIDE DERIVATIVES. | RHONE POULENC RORER SA (FR) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991010652-A1 | THIOFORMAMIDE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1991-07-25 | — | — | WO | disclosed |