Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10386050 | 0.88 | SLC6A4 (0.46) | SLC6A4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL9206729 | 0.87 | SLC6A4 (0.52) | SLC6A4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL9209421 | 0.86 | HTR1D (0.54) | HTR1A | |
| SCHEMBL6635167 | 0.79 | HTR1A (0.65) | SLC6A4HTR1AHTR7 | |
| SCHEMBL7346681 | 0.78 | SLC6A4 (0.52) | SLC6A4HTR1ADRD2DRD4HTR2A | |
| SCHEMBL7342683 | 0.75 | SLC6A4 (0.52) | SLC6A4HTR1ADRD2DRD4HTR2A | |
| SCHEMBL9209449 | 0.70 | MPO (0.62) | SLC6A4HTR1AHTR7HTR6 | |
| SCHEMBL7338414 | 0.70 | OPRM1 (0.66) | SLC6A4HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9213108 | 0.69 | HTR1A (0.69) | SLC6A4HTR1ADRD2HTR7 | |
| SCHEMBL6637427 | 0.68 | HTR1A (0.68) | SLC6A4HTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345808-B1 | 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines | BRISTOL MYERS SQUIBB CO (US) | 1995-01-11 | — | — | EP | claimed |
| US-4954502-A | Antidepressants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-09-04 | — | — | US | claimed |
| EP-0345808-A1 | 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines | Bristol-Myers Squibb Company (US) | 1989-12-13 | — | — | EP | claimed |