Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23411350 | 0.88 | KDM4E (0.64) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL29891520 | 0.88 | KDM4E (0.64) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL13469508 | 0.85 | TDP1 (0.48) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL6232527 | 0.85 | ALDH1A1 (0.52) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL7162258 | 0.84 | KDM4E (0.47) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL9217747 | 0.83 | KDM4E (0.50) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL568368 | 0.82 | ALDH1A1 (0.56) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL30099730 | 0.82 | ALDH1A1 (0.56) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL6232947 | 0.81 | GRM2 (0.47) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL18582737 | 0.80 | PDE9A (0.62) | KDM4EALDH1A1HPGDLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476544-B1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5192768-A | Antiinflammatory, hepatic insufficiency | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0476544-A1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |