SCHEMBL568368

SCHEMBL568368

Cn1c(=O)c(C#N)c(O)c2ccccc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.56
KMT2A Q03164 6/20 0.56
LMNA P02545 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
EGFR P00533 1/20 0.55
SRC P12931 1/20 0.55
KDM4E B2RXH2 11/20 0.52
HPGD P15428 4/20 0.52
RXFP1 Q9HBX9 2/20 0.52
MEN1 O00255 5/20 0.52
GAA P10253 4/20 0.52
MAPT P10636 3/20 0.52
CACNA1B Q00975 1/20 0.52
APBA1 Q02410 1/20 0.52
PRNP P04156 1/20 0.50
POLB P06746 2/20 0.49
GLA P06280 1/20 0.49
CYP2C19 P33261 1/20 0.49
HTT P42858 1/20 0.49
HSD17B10 Q99714 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30099730 1.00 ALDH1A1 (0.56) ALDH1A1KMT2ALMNASMN1; SMN2EGFR
SCHEMBL9216581 0.82 KDM4E (0.64) ALDH1A1KMT2ALMNASMN1; SMN2KDM4E
SCHEMBL29891520 0.81 KDM4E (0.64) ALDH1A1KMT2ALMNASMN1; SMN2KDM4E
SCHEMBL23411350 0.81 KDM4E (0.64) ALDH1A1KMT2ALMNASMN1; SMN2KDM4E
SCHEMBL29891965 0.81 EGFR (0.55) ALDH1A1KMT2ALMNASMN1; SMN2EGFR
SCHEMBL569008 0.81 EGFR (0.55) ALDH1A1KMT2ALMNASMN1; SMN2EGFR
SCHEMBL23410160 0.80 LMNA (0.41) KMT2ALMNASMN1; SMN2SRCKDM4E
SCHEMBL29891687 0.80 LMNA (0.41) KMT2ALMNASMN1; SMN2SRCKDM4E
SCHEMBL23410902 0.80 MAPT (0.41) ALDH1A1KMT2ALMNAEGFRSRC
SCHEMBL29892950 0.80 MAPT (0.41) ALDH1A1KMT2ALMNAEGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4081513-B1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2024-11-20 EP disclosed
US-20230061608-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-03-02 US disclosed
US-20230061608-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-03-02 US disclosed
CN-115103841-A Substituted quinolinonyl piperazine compounds useful as T cell activators 百时美施贵宝公司 2022-09-23 CN disclosed
WO-2021133748-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2021-07-01 WO disclosed
WO-2021133748-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2021-07-01 WO disclosed
EP-3354640-A2 MIF INHIBITORS AND THEIR USES Innovimmune Biotherapeutics, Inc. (US) 2018-08-01 EP disclosed
EP-3354640-A2 MIF INHIBITORS AND THEIR USES Innovimmune Biotherapeutics, Inc. (US) 2018-08-01 EP disclosed
EP-2696682-B1 MIF INHIBITORS AND THEIR USES INNOVIMMUNE BIOTHERAPEUTICS INC (US) 2018-03-21 EP disclosed
EP-2696682-B1 MIF INHIBITORS AND THEIR USES INNOVIMMUNE BIOTHERAPEUTICS INC (US) 2018-03-21 EP disclosed
US-9050334-B2 MIF inhibitors and their uses INNOV88 LLC (US) 2015-06-09 US disclosed
US-20150065480-A1 MIF INHIBITORS AND THEIR USES INNOVIMMUNE BIOTHERAPEUTICS, INC. (US) 2015-03-05 US disclosed
US-20150065480-A1 MIF INHIBITORS AND THEIR USES INNOVIMMUNE BIOTHERAPEUTICS, INC. (US) 2015-03-05 US disclosed
US-20150065480-A1 MIF INHIBITORS AND THEIR USES INNOVIMMUNE BIOTHERAPEUTICS, INC. (US) 2015-03-05 US disclosed
WO-2012142498-A2 MIF INHIBITORS AND THEIR USES INNOVIMMUNE BIOTHERAPEUTICS, INC. (US) 2012-10-18 WO disclosed
US-20120035150-A1 MIF INHIBITORS AND THEIR USES INNOV88 LLC 2012-02-09 US disclosed
US-20120035150-A1 MIF INHIBITORS AND THEIR USES INNOV88 LLC 2012-02-09 US disclosed
US-20120035150-A1 MIF INHIBITORS AND THEIR USES INNOV88 LLC 2012-02-09 US disclosed
WO-2012009649-A1 MIF INHIBITORS AND THEIR USES GAWECO ANDERSON (US) 2012-01-19 WO disclosed
US-20090060866-A1 PHOSPHADIAZINE HCV POLYMERASE INHIBITORS I AND II IDENIX PHARMACEUTICALS, INC. (US) 2009-03-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035150-A1 MIF INHIBITORS AND THEIR USES MIF, SERPINB1, HMGB2 ALDH1A1 790/4885KMT2A 3622/4885LMNA 3162/4885
US-20230061608-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS DGKZ, DGKA, DGKG ALDH1A1 3975/4885KMT2A 1558/4885LMNA 3271/4885
US-20150065480-A1 MIF INHIBITORS AND THEIR USES MIF, SERPINB1, HMGB2 ALDH1A1 790/4885KMT2A 3622/4885LMNA 3162/4885
US-20090060866-A1 PHOSPHADIAZINE HCV POLYMERASE INHIBITORS I AND II POLR2E, POLR2H, POLR2A ALDH1A1 1531/4885KMT2A 2571/4885LMNA 3922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.