Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208378 | 0.99 | MEN1 (0.47) | MEN1KMT2AACHEGRM5ADRA1B | |
| SCHEMBL9216049 | 0.96 | MEN1 (0.48) | MEN1KMT2AACHEGRM5ADRA1B | |
| SCHEMBL9209711 | 0.91 | MEN1 (0.50) | MEN1KMT2AGRM5ADRA1BKDM4E | |
| SCHEMBL31134777 | 0.89 | MEN1 (0.55) | MEN1KMT2AACHEGRM5ADRA1B | |
| SCHEMBL9204902 | 0.86 | SMN1; SMN2 (0.47) | ACHEALOX15DRD2HTR2CHTR2B | |
| SCHEMBL9204844 | 0.85 | MEN1 (0.49) | MEN1KMT2AACHEADRA1BHTR2A | |
| SCHEMBL9214240 | 0.84 | GRM5 (0.43) | GRM5DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9207494 | 0.84 | PARP1 (0.48) | MEN1KMT2AACHEDRD2HTR2A | |
| SCHEMBL9207673 | 0.83 | MEN1 (0.47) | MEN1KMT2AADRA1BALOX15DRD2 | |
| SCHEMBL9212186 | 0.83 | SMN1; SMN2 (0.48) | ALOX15DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |