Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204844 | 0.94 | MEN1 (0.49) | MEN1KMT2AADRA1BDRD3DRD4 | |
| SCHEMBL9216049 | 0.87 | MEN1 (0.48) | MEN1KMT2AADRA1BDRD3DRD4 | |
| SCHEMBL9208378 | 0.84 | MEN1 (0.47) | MEN1KMT2AADRA1BDRD2ALOX15 | |
| SCHEMBL9216770 | 0.83 | MEN1 (0.46) | MEN1KMT2AADRA1BDRD2ALOX15 | |
| SCHEMBL9207883 | 0.82 | NAAA (0.40) | ITGB3ITGA2B | |
| SCHEMBL9209711 | 0.81 | MEN1 (0.50) | MEN1KMT2AADRA1BITGB3ITGA2B | |
| SCHEMBL9212186 | 0.79 | SMN1; SMN2 (0.48) | DRD3HTR1AHCN4CHRM2SLC6A4 | |
| SCHEMBL9207494 | 0.78 | PARP1 (0.48) | MEN1KMT2ADRD2 | |
| SCHEMBL9214236 | 0.76 | MEN1 (0.50) | MEN1KMT2AADRA1BDRD3DRD4 | |
| SCHEMBL9204902 | 0.76 | SMN1; SMN2 (0.47) | DRD3DRD4HTR1AHCN4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |