Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216049 | 0.89 | MEN1 (0.48) | PARP1DRD2ACHEHTR2AMEN1 | |
| SCHEMBL9208378 | 0.85 | MEN1 (0.47) | DRD2ACHEHTR2AMEN1KMT2A | |
| SCHEMBL9216770 | 0.84 | MEN1 (0.46) | DRD2ACHEHTR2AMEN1KMT2A | |
| SCHEMBL9209711 | 0.81 | MEN1 (0.50) | HTR2AMEN1KMT2AHTR2CHTR2B | |
| SCHEMBL9204844 | 0.80 | MEN1 (0.49) | ACHEHTR2AMEN1KMT2AHTR2C | |
| SCHEMBL9212186 | 0.80 | SMN1; SMN2 (0.48) | PARP1DRD2HTR2AEEDHTR2C | |
| SCHEMBL9216697 | 0.79 | EED (0.44) | ACHEHTR2AEEDHTR2CHTR2B | |
| SCHEMBL9207673 | 0.78 | MEN1 (0.47) | DRD2MEN1KMT2A | |
| SCHEMBL9204902 | 0.76 | SMN1; SMN2 (0.47) | DRD2ACHEHTR2CHTR2BEHMT2 | |
| SCHEMBL16858398 | 0.76 | ACHE (0.43) | ACHEHTR2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |