Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221111 | 0.99 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9218110 | 0.95 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9219766 | 0.94 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9218499 | 0.93 | POLB (0.54) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9212376 | 0.92 | HPGD (0.52) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9683410 | 0.92 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9216907 | 0.90 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9217935 | 0.89 | LMNA (0.42) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9218881 | 0.88 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2LMNATSHRHPGD | |
| SCHEMBL9219589 | 0.88 | TP53 (0.45) | ALDH1A1SMN1; SMN2LMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |