Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | MMP12 | P39900 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218788 | 0.93 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TP53POLBMMP3 | |
| SCHEMBL9219766 | 0.93 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TP53POLBMMP3 | |
| SCHEMBL9213690 | 0.93 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1TP53POLBMMP3 | |
| SCHEMBL9218881 | 0.91 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1TP53POLBMMP3 | |
| SCHEMBL9216907 | 0.89 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TP53POLBMMP3 | |
| SCHEMBL9221111 | 0.88 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1TP53POLBKMT2A | |
| SCHEMBL9216807 | 0.87 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1TP53POLBKMT2A | |
| SCHEMBL9212149 | 0.83 | SCN2A (0.50) | SMN1; SMN2ALDH1A1TP53POLBMMP3 | |
| SCHEMBL9218548 | 0.83 | TDP1 (0.57) | SMN1; SMN2ALDH1A1POLBHTTKDM4E | |
| SCHEMBL9218110 | 0.82 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TP53POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |