Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 7/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PTAFR | P25105 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Sulfide SCHEMBL28950276 | 0.73 | GFER (0.33) | GFERPTAFRNISCH | |
| SCHEMBL10686037 | 0.69 | TP53 (0.32) | GFER | |
| SCHEMBL761104 | 0.69 | — | — | |
| SCHEMBL3349858 | 0.69 | ALDH1A1 (0.41) | CHRM5CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL4721848 | 0.67 | MAPT (0.42) | RAB9AHSD17B10MAPK1 | |
| SCHEMBL4607483 | 0.67 | ALDH1A1 (0.44) | ALDH1A1RAB9ASMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL11354407 | 0.67 | TP53 (0.34) | CHRM5CHRM3CHRM2CHRM4CHRM1 | |
| SCHEMBL27617462 | 0.65 | PTAFR (0.31) | GFERPTAFRNISCH | |
| SCHEMBL28143517 | 0.61 | PRKDC (0.53) | ALDH1A1RAB9AHSD17B10MAPK1 | |
| SCHEMBL40342 | 0.60 | TNKS (0.35) | ALDH1A1RAB9ASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660833-A1 | 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO 2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-05 | — | — | EP | claimed |