Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.45 |
| ▸ | RORA | P35398 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | RORB | Q92753 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 3/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218908 | 0.86 | PLK1 (0.46) | PGRRORARORCRORBPLK1 | |
| SCHEMBL9216799 | 0.73 | KDM4E (0.42) | UTS2RPGRRORARORCRORB | |
| SCHEMBL6523698 | 0.70 | TSHR (0.47) | PGRRORARORCRORBKDM4E | |
| SCHEMBL6515436 | 0.70 | CHEK1 (0.51) | PGRRORARORCRORBPLK1 | |
| SCHEMBL21067780 | 0.70 | CYP1A2 (0.48) | PGRPLK1KDM4EGAANPC1 | |
| SCHEMBL6514910 | 0.69 | CHEK1 (0.49) | PGRRORARORCRORBPLK1 | |
| SCHEMBL6518602 | 0.69 | AURKA (0.41) | PGRRORARORCRORBPLK1 | |
| SCHEMBL6518571 | 0.69 | HDAC3 (0.41) | PGRRORARORCRORBKDM4E | |
| SCHEMBL6518514 | 0.68 | MEN1 (0.43) | PLK1KDM4ELMNAHPGDHTT | |
| SCHEMBL6521770 | 0.68 | HDAC3 (0.40) | PLK1KDM4ENPC1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476544-B1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5192768-A | Antiinflammatory, hepatic insufficiency | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0476544-A1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |