Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217657 | 0.86 | UTS2R (0.46) | PLK1APOBEC3GKDM4EALDH1A1LMNA | |
| SCHEMBL9213798 | 0.73 | PGR (0.49) | KDM4EALDH1A1LMNAHPGDPOLB | |
| SCHEMBL21067780 | 0.73 | CYP1A2 (0.48) | PLK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL6518602 | 0.72 | AURKA (0.41) | PLK1APOBEC3GKDM4EALDH1A1LMNA | |
| SCHEMBL6514910 | 0.72 | CHEK1 (0.49) | PLK1APOBEC3GKDM4EALDH1A1LMNA | |
| SCHEMBL10558211 | 0.72 | TSHR (0.43) | HSD17B10ADORA3MAPTTSHRTP53 | |
| SCHEMBL6508661 | 0.71 | TOP2A (0.53) | PLK1APOBEC3GKDM4ERXFP1HTT | |
| SCHEMBL6523698 | 0.71 | TSHR (0.47) | KDM4EALDH1A1LMNAHPGDPOLB | |
| SCHEMBL6515436 | 0.71 | CHEK1 (0.51) | PLK1APOBEC3GKDM4EALDH1A1LMNA | |
| SCHEMBL10556775 | 0.71 | ADORA3 (0.46) | LMNAADORA3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4356486-A | — | — | None | — | — | JP | disclosed |
| EP-0476544-B1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5192768-A | Antiinflammatory, hepatic insufficiency | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| JP-H04356486-A | PYRAZOLOQUINOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO LTD | 1992-12-10 | — | — | JP | disclosed |
| EP-0476544-A1 | Pyrazoloquinoline derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |