SCHEMBL921774

SCHEMBL921774

C#CCCOc1cccc(CNC(=O)c2cccnc2N)c1F

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 3/20 0.46
LMNA P02545 1/20 0.42
MET P08581 1/20 0.40
HPGD P15428 2/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
RCE1 Q9Y256 1/20 0.39
KLKB1 P03952 1/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
PRKCI P41743 2/20 0.38
PDPK1 O15530 1/20 0.38
ADORA2A P29274 2/20 0.37
ADORA1 P30542 2/20 0.37
PLA2G1B P04054 1/20 0.37
ATG4B Q9Y4P1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920215 0.96 MAPK8 (0.46) MAPK8LMNAMETHPGDKDM4E
SCHEMBL922609 0.95 MAPK8 (0.45) MAPK8LMNAMETHPGDKDM4E
SCHEMBL921657 0.94 MAPK8 (0.44) MAPK8LMNAMETHPGDKDM4E
SCHEMBL922791 0.90 MAPK8 (0.47) MAPK8LMNAMETHPGDKDM4E
SCHEMBL921812 0.88 MAPK8 (0.44) MAPK8LMNAMETHPGDKDM4E
SCHEMBL923643 0.87 LMNA (0.45) MAPK8LMNAMETHPGDKDM4E
SCHEMBL921803 0.87 LMNA (0.45) MAPK8LMNAMETHPGDKDM4E
SCHEMBL922054 0.87 KLKB1 (0.38) MAPK8LMNAMETHPGDKDM4E
SCHEMBL920190 0.87 LMNA (0.49) MAPK8LMNAMETHPGDKDM4E
SCHEMBL919407 0.86 LMNA (0.48) MAPK8LMNAMETHPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK8 2313/4885LMNA 4812/4885MET 3120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.