Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217713 | 0.94 | REN (0.50) | KLK7KLK5CTSSMMP9SYK | |
| SCHEMBL27510152 | 0.92 | CTSS (0.53) | KLK7KLK5CTSSMMP9SYK | |
| SCHEMBL9217707 | 0.89 | SYK (0.46) | KLK7KLK5CTSSMMP9SYK | |
| SCHEMBL8430460 | 0.89 | KLK7 (0.54) | KLK7KLK5CTSSMMP9PPARA | |
| SCHEMBL12292883 | 0.87 | PPARA (0.55) | KLK7KLK5CTSSPPARASYK | |
| SCHEMBL7294995 | 0.86 | CTSS (0.56) | KLK7KLK5CTSSMMP9PPARA | |
| SCHEMBL14037329 | 0.86 | SYK (0.53) | KLK7KLK5CTSSSYKCTSK | |
| SCHEMBL25491606 | 0.86 | KLK7 (0.59) | KLK7KLK5CTSSPPARASYK | |
| SCHEMBL5419241 | 0.86 | KLK7 (0.59) | KLK7KLK5CTSSPPARASYK | |
| SCHEMBL12292731 | 0.85 | BACE1 (0.51) | CTSSPPARACTSKRENCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |