Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 6/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220615 | 0.91 | PLK1 (0.53) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL3143484 | 0.76 | PLK1 (0.49) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL9538244 | 0.72 | PLK1 (0.43) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL22048856 | 0.71 | HTR2A (0.45) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL17901964 | 0.69 | PLK1 (0.58) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL17901904 | 0.69 | PLK1 (0.58) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL9535703 | 0.68 | PLK1 (0.61) | PLK1CSNK2A1PLK3HTR2AHTR1A | |
| SCHEMBL17895977 | 0.68 | PLK1 (0.42) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL17895980 | 0.68 | PLK1 (0.42) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL22980483 | 0.68 | PLK1 (0.79) | PLK1CSNK2A1PLK3ELANEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | claimed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | claimed |
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |