Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533236 | 0.75 | PLK1 (0.41) | PLK1CSNK2A1PLK3HTR2AHTR1A | |
| SCHEMBL9218236 | 0.72 | PLK1 (0.47) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL9220615 | 0.70 | PLK1 (0.53) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL9534430 | 0.66 | PLK1 (0.56) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL3143484 | 0.61 | PLK1 (0.49) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL3142557 | 0.60 | PLK1 (0.93) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL1986758 | 0.60 | PLK1 (1.00) | PLK1CSNK2A1PLK3ELANEHIF1A | |
| SCHEMBL22980483 | 0.59 | PLK1 (0.79) | PLK1CSNK2A1PLK3ELANEHTR2A | |
| SCHEMBL9535703 | 0.59 | PLK1 (0.61) | PLK1CSNK2A1PLK3HTR2AHTR1A | |
| SCHEMBL5258807 | 0.58 | PLK1 (0.50) | PLK1CSNK2A1PLK3ELANEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0276835-A1 | Pyrazolothiopyranopyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734431-A | Thiopyranodipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |