Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.45 |
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22048623 | 0.92 | PLK1 (0.50) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| SCHEMBL9218236 | 0.71 | PLK1 (0.47) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.68 | PLK1 (0.59) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| SCHEMBL17901964 | 0.67 | PLK1 (0.58) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| SCHEMBL17901904 | 0.67 | PLK1 (0.58) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| SCHEMBL9535703 | 0.66 | PLK1 (0.61) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| SCHEMBL9220615 | 0.66 | PLK1 (0.53) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| SCHEMBL22980483 | 0.66 | PLK1 (0.79) | HTR2AHTR1ADRD2PLK1CSNK2A1 | |
| SCHEMBL9431516 | 0.65 | CYP19A1 (0.56) | HTR2AHTR1ADRD2HTR2CCYP3A4 | |
| SCHEMBL9533236 | 0.65 | PLK1 (0.41) | HTR2AHTR1ADRD2PLK1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2023-01-12 | — | — | US | disclosed |
| EP-3828182-A1 | FUSED RING LACTAM DERIVATIVES | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2021-06-02 | — | — | EP | disclosed |
| US-10745401-B2 | Condensed lactam derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-18 | — | — | US | disclosed |
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-13 | — | — | US | disclosed |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255432-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | HTR2A 947/4885HTR1A 362/4885DRD2 430/4885 |
| US-10745401-B2 | Condensed lactam derivative | PSEN1, GRIN1, HDAC1 | HTR2A 947/4885HTR1A 362/4885DRD2 430/4885 |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | HTR1A, HTR5A, TPH1 | HTR2A 10/4885HTR1A 1/4885DRD2 59/4885 |
| US-20200172543-A1 | CONDENSED LACTAM DERIVATIVE | PSEN1, GRIN1, HDAC1 | HTR2A 947/4885HTR1A 362/4885DRD2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.