Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9431302 | 0.91 | L3MBTL1 (0.49) | NPC1CYP19A1ESR1ESR2MAPT | |
| Hydrochloric Acid SCHEMBL9213805 | 0.90 | L3MBTL1 (0.48) | NPC1CYP19A1MAPTL3MBTL1MMP2 | |
| Hydrochloric Acid SCHEMBL9220707 | 0.85 | L3MBTL1 (0.43) | NPC1MAPTL3MBTL1MMP2MEN1 | |
| SCHEMBL9431764 | 0.83 | L3MBTL1 (0.43) | NPC1POLBMAPTL3MBTL1MMP2 | |
| SCHEMBL9221219 | 0.83 | CA1 (0.43) | CYP19A1ESR1ESR2MEN1KMT2A | |
| SCHEMBL9430278 | 0.82 | BCHE (0.50) | NPC1MEN1KMT2APTPN1 | |
| Hydrochloric Acid SCHEMBL9216724 | 0.82 | L3MBTL1 (0.42) | NPC1POLBMAPTL3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL9215520 | 0.82 | L3MBTL1 (0.52) | NPC1POLBMAPTL3MBTL1MMP2 | |
| SCHEMBL9430879 | 0.82 | L3MBTL1 (0.42) | NPC1MAPTL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9221124 | 0.80 | L3MBTL1 (0.48) | MAPTL3MBTL1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |