Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | F12 | P00748 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430877 | 0.93 | TP53 (0.54) | TP53MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9219757 | 0.84 | TP53 (0.63) | TP53MAPTALDH1A1HTTKDM4E | |
| SCHEMBL9210201 | 0.83 | MCL1 (0.57) | TP53MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9213365 | 0.82 | TP53 (0.67) | TP53MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9218392 | 0.81 | KDM4E (0.51) | TP53MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9431056 | 0.80 | MAPT (0.53) | TP53MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9217469 | 0.80 | KDM4E (0.54) | TP53MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9220878 | 0.80 | TP53 (0.60) | TP53NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL9430174 | 0.80 | KDM4E (0.59) | TP53MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9215004 | 0.80 | NPC1 (0.47) | TP53MAPTNPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |