Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397974 | 0.92 | TSHR (0.33) | TSHRMEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL10552009 | 0.86 | — | — | |
| SCHEMBL17333435 | 0.79 | — | — | |
| SCHEMBL1767925 | 0.79 | CA12 (0.36) | TSHRSMN1; SMN2 | |
| SCHEMBL17517388 | 0.78 | ADH1C (0.31) | TSHRSMN1; SMN2 | |
| SCHEMBL96463 | 0.78 | — | — | |
| SCHEMBL25036979 | 0.77 | KDM5A (0.32) | TSHRSMN1; SMN2 | |
| SCHEMBL5518857 | 0.76 | — | — | |
| SCHEMBL27084 | 0.76 | — | — | |
| SCHEMBL27668697 | 0.76 | ALDH1A1 (0.38) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459269-A | 14-halo-camptothecins | NORTH CAROLINA STATE UNIVERSITY (US) | 1995-10-17 | — | — | US | disclosed |
| US-5428166-A | Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1995-06-27 | — | — | US | disclosed |