Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351984 | 0.84 | FDPS (0.38) | FDPSLMNAHSD17B10 | |
| SCHEMBL11680689 | 0.84 | FDPS (0.44) | FDPS | |
| SCHEMBL3833063 | 0.81 | MEN1 (0.35) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL2138066 | 0.81 | CYP2D6 (0.44) | MEN1ALDH1A1CYP1A2THRBKMT2A | |
| SCHEMBL6038124 | 0.81 | LMNA (0.36) | FDPSLMNA | |
| SCHEMBL10926903 | 0.80 | KMT2A (0.36) | FDPSLMNAHSD17B10MEN1ALDH1A1 | |
| SCHEMBL2448745 | 0.80 | FFAR3 (0.38) | FDPSLMNAHSD17B10MEN1ALDH1A1 | |
| SCHEMBL29025723 | 0.78 | KDM4C (0.37) | FDPSLMNAHSD17B10MEN1ALDH1A1 | |
| SCHEMBL9179083 | 0.78 | KDM4C (0.37) | FDPSLMNAHSD17B10MEN1ALDH1A1 | |
| SCHEMBL28440778 | 0.76 | CYP2D6 (0.44) | MEN1ALDH1A1CYP1A2THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES. | PFIZER HOSPITAL PROD (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017061-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |