Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | G6PD | P11413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214216 | 0.87 | NPC1 (0.37) | ALDH3A1ALDH1A1ALDH2MITFHSP90AA1 | |
| Tenidap SCHEMBL24922 | 0.81 | MEN1 (0.42) | ALDH1A1HSP90AA1HTTNPSR1KDM4E | |
| Tenidap SCHEMBL3751880 | 0.81 | MEN1 (0.42) | ALDH1A1HSP90AA1HTTNPSR1KDM4E | |
| Tenidap SCHEMBL3751878 | 0.81 | MEN1 (0.42) | ALDH1A1HSP90AA1HTTNPSR1KDM4E | |
| SCHEMBL9219844 | 0.81 | GSK3B (0.35) | ALDH3A1ALDH1A1ALDH2MITFHSP90AA1 | |
| SCHEMBL9215467 | 0.80 | ALDH1A1 (0.36) | ALDH3A1ALDH1A1ALDH2MITFHSP90AA1 | |
| Tenidap SCHEMBL9216494 | 0.79 | ALDH1A1 (0.33) | ALDH3A1ALDH1A1ALDH2MITFHSP90AA1 | |
| SCHEMBL3676246 | 0.79 | ALDH1A1 (0.33) | ALDH3A1ALDH1A1ALDH2MITFHSP90AA1 | |
| SCHEMBL9219355 | 0.74 | GRM1 (0.34) | ALDH3A1ALDH1A1ALDH2MITFHSP90AA1 | |
| SCHEMBL9217917 | 0.73 | ALDH1A1 (0.41) | ALDH3A1ALDH1A1ALDH2HSP90AA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421749-B1 | 3-Aroyl-2-oxindole-1-carboxamides | PFIZER (US) | 1995-12-13 | — | — | EP | disclosed |
| US-5059693-A | REDUCTIVE DEHALOGENATION | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0421749-A2 | 3-Aroyl-2-oxindole-1-carboxamides | PFIZER INC. (US) | 1991-04-10 | — | — | EP | disclosed |