Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219298 | 1.00 | EPHX1 (0.39) | EPHX1CPB2CTSKMETAP2METAP1 | |
| SCHEMBL9224178 | 0.82 | CTSK (0.40) | CPB2CTSKCTSLCTSB | |
| SCHEMBL9556645 | 0.82 | CTSK (0.40) | CPB2CTSKCTSLCTSB | |
| SCHEMBL9556641 | 0.82 | CTSK (0.40) | CPB2CTSKCTSLCTSB | |
| SCHEMBL8910237 | 0.82 | CTSK (0.34) | EPHX1CTSKMETAP2METAP1ALOX5 | |
| SCHEMBL8910229 | 0.82 | CTSK (0.34) | EPHX1CTSKMETAP2METAP1ALOX5 | |
| SCHEMBL9224171 | 0.82 | CTSK (0.40) | CPB2CTSKCTSLCTSB | |
| SCHEMBL8909191 | 0.82 | CTSK (0.34) | EPHX1CTSKMETAP2METAP1ALOX5 | |
| SCHEMBL9226123 | 0.79 | CTSK (0.35) | CTSKMETAP2KMT2ACTSLCTSB | |
| SCHEMBL9226116 | 0.79 | CTSK (0.35) | CTSKMETAP2KMT2ACTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |