Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.40 |
| ▸ | CTSL | P07711 | 6/20 | 0.38 |
| ▸ | CTSB | P07858 | 6/20 | 0.38 |
| ▸ | CTSH | P09668 | 4/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556645 | 1.00 | CTSK (0.40) | CTSKCTSLCTSBCTSHREN | |
| SCHEMBL9556641 | 1.00 | CTSK (0.40) | CTSKCTSLCTSBCTSHREN | |
| SCHEMBL9224171 | 1.00 | CTSK (0.40) | CTSKCTSLCTSBCTSHREN | |
| SCHEMBL9226116 | 0.85 | CTSK (0.35) | CTSKCTSLCTSBCTSHREN | |
| SCHEMBL9226123 | 0.85 | CTSK (0.35) | CTSKCTSLCTSBCTSHREN | |
| SCHEMBL9219298 | 0.82 | EPHX1 (0.39) | CTSKCTSLCTSBCPB2 | |
| SCHEMBL8909191 | 0.82 | CTSK (0.34) | CTSKCTSLCTSBCTSHREN | |
| SCHEMBL8910229 | 0.82 | CTSK (0.34) | CTSKCTSLCTSBCTSHREN | |
| SCHEMBL9219308 | 0.82 | EPHX1 (0.39) | CTSKCTSLCTSBCPB2 | |
| SCHEMBL8910237 | 0.82 | CTSK (0.34) | CTSKCTSLCTSBCTSHREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |