Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29065552 | 0.81 | ALOX5 (0.36) | ANPEP | |
| SCHEMBL17834052 | 0.77 | ANPEP (0.42) | ANPEPALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL351588 | 0.75 | ALDH1A1 (0.42) | ANPEPALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL351586 | 0.75 | ALDH1A1 (0.42) | ANPEPALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL351587 | 0.75 | ALDH1A1 (0.42) | ANPEPALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL13163204 | 0.75 | ALDH1A1 (0.42) | ANPEPALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL7296939 | 0.75 | ANPEP (0.39) | ANPEPALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL29068106 | 0.75 | ANPEP (0.33) | ANPEP | |
| SCHEMBL29068108 | 0.75 | ANPEP (0.33) | ANPEP | |
| SCHEMBL13163202 | 0.74 | ALDH1A1 (0.41) | ANPEPALDH1A1SMN1; SMN2DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |