Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992955 | 0.84 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9170597 | 0.84 | RAB9A (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9171743 | 0.82 | AR (0.39) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9172768 | 0.82 | RAB9A (0.55) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9215696 | 0.81 | RAB9A (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9214077 | 0.80 | RAB9A (0.37) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9222033 | 0.78 | RAB9A (0.34) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9222652 | 0.77 | GSTP1 (0.47) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL8993290 | 0.76 | GPR119 (0.41) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9215756 | 0.76 | SRC (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |