Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992965 | 0.85 | GPR119 (0.41) | RAB9ASMN1; SMN2NPC1LMNAPOLB | |
| SCHEMBL9213595 | 0.84 | UCHL1 (0.54) | LMNAMAPTALDH1A1TP53MEN1 | |
| SCHEMBL9220305 | 0.84 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1LMNAPOLB | |
| SCHEMBL8992955 | 0.83 | NPC1 (0.43) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL9214077 | 0.82 | RAB9A (0.37) | RAB9ASMN1; SMN2NPC1LMNAPOLB | |
| SCHEMBL8993213 | 0.82 | RAB9A (0.46) | RAB9ASMN1; SMN2NPC1LMNAPOLB | |
| SCHEMBL8992990 | 0.82 | KMT2A (0.48) | RAB9ASMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL9219403 | 0.81 | NPC1 (0.39) | RAB9ASMN1; SMN2NPC1LMNAPOLB | |
| SCHEMBL8993290 | 0.81 | GPR119 (0.41) | RAB9ASMN1; SMN2NPC1LMNAPOLB | |
| SCHEMBL9221670 | 0.81 | RAB9A (0.45) | RAB9ASMN1; SMN2NPC1LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |