Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.38 |
| ▸ | BCR | P11274 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214289 | 0.87 | KDR (0.50) | ABL1MAPTKDRLMNATDP1 | |
| SCHEMBL9217924 | 0.86 | KMT2A (0.54) | KMT2ANPC1RAB9AABL1MAPT | |
| SCHEMBL9219409 | 0.84 | SMPD3 (0.41) | KMT2ANPC1RAB9AMAPTMEN1 | |
| SCHEMBL8993148 | 0.84 | KMT2A (0.41) | KMT2ANPC1RAB9AABL1ABCB1 | |
| SCHEMBL9221092 | 0.83 | FYN (0.43) | ABL1MAPTGAAKDR | |
| SCHEMBL9221145 | 0.81 | CYP17A1 (0.36) | KMT2ANPC1RAB9AMAPTKDR | |
| SCHEMBL9219353 | 0.80 | MAPT (0.56) | KMT2ANPC1RAB9AABL1MAPT | |
| SCHEMBL8992990 | 0.79 | KMT2A (0.48) | KMT2ANPC1RAB9AMAPTKDR | |
| SCHEMBL9219419 | 0.78 | ALDH1A1 (0.34) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL9218594 | 0.78 | RAB9A (0.40) | KMT2ANPC1RAB9AMAPTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |