Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219950 | 1.00 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL9221627 | 0.87 | TERT (0.54) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL9221630 | 0.87 | TERT (0.54) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL10888892 | 0.86 | MAPT (0.55) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL9325989 | 0.86 | MAPT (0.55) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL9325994 | 0.86 | MAPT (0.55) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL9219537 | 0.86 | KMO (0.51) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL9219542 | 0.86 | KMO (0.51) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL184276 | 0.84 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL184275 | 0.84 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HPGDHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636124-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021170-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |