Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021387 | 0.71 | DRD4 (1.00) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9211977 | 0.71 | DRD2 (0.31) | DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL8021566 | 0.70 | DRD4 (0.97) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9212631 | 0.70 | DRD4 (0.55) | DRD4DRD2CDK8CCNCCDK19 | |
| SCHEMBL8011151 | 0.66 | DRD4 (1.00) | DRD4DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8021392 | 0.65 | DRD4 (0.97) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL21328489 | 0.65 | TYMS (0.43) | FLT3MAPT | |
| SCHEMBL6194955 | 0.63 | CDK8 (0.55) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL24427236 | 0.62 | HSP90AA1 (0.66) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9215792 | 0.62 | CCNA2 (0.43) | DRD4DRD2MAPK10RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |