SCHEMBL9220197

SCHEMBL9220197

N#Cc1nc(-c2ccc(Cl)cc2Cl)[nH]c1C#N

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.51
LMNA P02545 1/20 0.51
GAA P10253 1/20 0.51
HPGD P15428 1/20 0.51
KMT2A Q03164 1/20 0.51
GUSB P08236 1/20 0.45
USP8 P40818 2/20 0.42
USP7 Q93009 2/20 0.42
USP47 Q96K76 1/20 0.42
KDM4E B2RXH2 2/20 0.42
MAPT P10636 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
NPBWR1 P48145 1/20 0.41
CXCR2 P25025 4/20 0.41
GSK3B P49841 2/20 0.39
GSK3A P49840 1/20 0.39
DYRK1A Q13627 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
PSMB8 P28062 1/20 0.39
HSP90AA1 P07900 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9226157 0.84 HPGD (0.50) MEN1LMNAGAAHPGDKMT2A
SCHEMBL9220607 0.82 CTSS (0.40) MEN1LMNAGAAHPGDKMT2A
SCHEMBL10696465 0.81 PTGES (0.49) LMNAGAAHPGDGUSBKDM4E
SCHEMBL9220606 0.79 MEN1 (0.52) MEN1LMNAGAAHPGDKMT2A
SCHEMBL10697288 0.78 MEN1 (0.48) MEN1LMNAGAAHPGDKMT2A
SCHEMBL9371853 0.78 CHEK2 (0.39) MEN1LMNAGAAHPGDKMT2A
SCHEMBL10695576 0.78 ERBB2 (0.47) MEN1LMNAGAAHPGDKMT2A
SCHEMBL10695348 0.76 GAA (0.47) LMNAGAAHPGDKDM4ENPBWR1
SCHEMBL10696178 0.74 ALOX15 (0.45) LMNAHPGDCXCR2
SCHEMBL9370878 0.72 APP (0.47) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0283173-A1 Pesticidal method using 2-phenylimidazole derivatives RHONE-POULENC AGRICULTURE LIMITED (GB) 1988-09-21 EP claimed
US-5380865-A Halogen substituents MAY & BAKER LIMITED (GB) 1995-01-10 US disclosed
US-5206257-A Controlling plant nematodes, helminth, protozoa MAY & BAKER LIMITED (GB) 1993-04-27 US disclosed
EP-0283173-A1 Pesticidal method using 2-phenylimidazole derivatives RHONE-POULENC AGRICULTURE LIMITED (GB) 1988-09-21 EP disclosed
EP-0269238-A1 Imidazoles and their compositions for plant growth regulation MAY & BAKER LIMITED (GB) 1988-06-01 EP disclosed