Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11856341 | 0.83 | HPGD (0.53) | MAPTKMT2ANR4A1ALDH1A1KDM4E | |
| SCHEMBL9212096 | 0.83 | MAPT (0.46) | MAPTKMT2ANR4A1KDM4ERAB9A | |
| SCHEMBL20509554 | 0.79 | ALDH1A1 (0.60) | KMT2AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL830740 | 0.77 | KMT2A (0.60) | MAPTKMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL2393841 | 0.77 | MAPT (0.51) | MAPTKMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL1887188 | 0.76 | KMT2A (0.77) | MAPTKMT2AKDM4EHTTRAB9A | |
| SCHEMBL11525777 | 0.75 | KDM4E (0.48) | MAPTKMT2ANR4A1ALDH1A1KDM4E | |
| SCHEMBL7585613 | 0.75 | NR4A1 (0.56) | MAPTKMT2ANR4A1ALDH1A1KDM4E | |
| SCHEMBL12405804 | 0.74 | NR4A1 (0.65) | MAPTKMT2ANR4A1ALDH1A1KDM4E | |
| SCHEMBL1820870 | 0.74 | NR4A1 (0.65) | KMT2ANR4A1ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |