Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405657 | 0.93 | ENPP2 (0.57) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL11327076 | 0.93 | ENPP2 (0.57) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL30201625 | 0.91 | ENPP2 (0.56) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL13249184 | 0.91 | CYCS (0.56) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL21043930 | 0.90 | ENPP2 (0.55) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL15134783 | 0.87 | TOP1 (0.55) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL10587131 | 0.87 | TOP1 (0.55) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL8355904 | 0.87 | TOP1 (0.55) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL31154457 | 0.87 | TOP1 (0.55) | TOP1ENPP2MAPTRAB9ACYCS | |
| SCHEMBL30556440 | 0.87 | TOP1 (0.55) | TOP1ENPP2MAPTRAB9ACYCS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345171-B1 | Metalloporphyrine derivatives, their therapeutical use and their use in the preparation of hybrid molecules | CENTRE NAT RECH SCIENT (FR) | 1995-12-13 | — | — | EP | disclosed |
| EP-0345171-A1 | Metalloporphyrine derivatives, their therapeutical use and their use in the preparation of hybrid molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1989-12-06 | — | — | EP | disclosed |