Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2623697 | 0.95 | HDAC8 (0.65) | ALDH1A1ACHEKMT2ATDP1HDAC8 | |
| SCHEMBL5272078 | 0.93 | HDAC8 (0.68) | ALDH1A1KMT2ATDP1HDAC8HDAC3 | |
| SCHEMBL8897691 | 0.93 | HDAC8 (0.68) | ALDH1A1KMT2ATDP1HDAC8HDAC3 | |
| SCHEMBL29642483 | 0.89 | ALDH1A1 (0.57) | ALDH1A1KMT2ATDP1HDAC8HDAC3 | |
| SCHEMBL3756580 | 0.89 | ALDH1A1 (0.57) | ALDH1A1KMT2ATDP1HDAC8HDAC3 | |
| SCHEMBL11754615 | 0.85 | ALDH1A1 (0.62) | ALDH1A1ACHEKMT2ATDP1HDAC8 | |
| SCHEMBL5041554 | 0.84 | ALDH1A1 (0.60) | ALDH1A1ACHEKMT2ATDP1HDAC8 | |
| SCHEMBL29459522 | 0.84 | KMT2A (0.73) | ALDH1A1ACHEKMT2ATDP1HDAC8 | |
| SCHEMBL877279 | 0.84 | KMT2A (0.73) | ALDH1A1ACHEKMT2ATDP1HDAC8 | |
| SCHEMBL10672732 | 0.83 | ALDH1A1 (0.56) | ALDH1A1ACHEKMT2ATDP1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996033199-A1 | PROCESS FOR MAKING 1-HYDROXYBISPHOSPHONATES | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | claimed |
| US-5159108-A | Process for preparing an antihypercalcemic agent | MERCK & CO., INC. (US) | 1992-10-27 | — | — | US | claimed |
| US-20160200670-A1 | RADIOPAQUE MONOMERS, POLYMERS, MICROSPHERES, AND METHODS RELATED THERETO | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2016-07-14 | — | — | US | disclosed |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | DERMIRA (CANADA), INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-8445694-B2 | Hydrazonopyrazole derivatives and their use as therapeutics | DERMIRA (CANADA), INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110237783-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | Valocor Therapeutics, Inc. (CA) | 2011-09-29 | — | — | US | disclosed |
| US-7875728-B2 | tert-butyl-[5-methyl-4-(phenylhydrazono)-4H-pyrazol-3-yl]amine; 4-(3-fluorophenylhydrazono)-5-methyl-2H-pyrazol-3-ylamine; demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death | Valocor Therapeutics, Inc. (CA) | 2011-01-25 | — | — | US | disclosed |
| US-7214794-B2 | Capable of crossing cell membrane; induction apoptosis in human cancer cells | BRACCO S.P.A. (IT) | 2007-05-08 | — | — | US | disclosed |
| US-7214794-B2 | Capable of crossing cell membrane; induction apoptosis in human cancer cells | BRACCO S.P.A. (IT) | 2007-05-08 | — | — | US | disclosed |
| CN-1896078-A | Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors | ASTRAZENECA AB (SE) | 2007-01-17 | — | — | CN | disclosed |
| CN-1264846-C | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | CN | disclosed |
| US-4957920-A | INOTROPIC | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0354881-A1 | Acetazolamide-related compounds, process for their preparation, and pharmaceutical composition containing the same | ISTITUTO CHIMICO INTERNAZIONALE DR. GIUSEPPE RENDE S.R.L. (IT) | 1990-02-14 | — | — | EP | disclosed |
| US-4883815-A | CONTROL OR PREVENTION OF CEREBRAL INSUFFICIENCY, IMPROVEMENT OF COGNITIVE FUNCTIONS | HOFFMANN-LA ROCHE INC. (US) | 1989-11-28 | — | — | US | disclosed |
| CN-1036952-A | Hydrogenated cinnamic acid derivative and its method for making | HOFFMANN LA ROCHE (CH) | 1989-11-08 | — | — | CN | disclosed |
| US-4670448-A | ANTIINFLAMMATORY AGENTS, HISTAMINE H2-ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1987-06-02 | — | — | US | disclosed |
| US-4399151-A | USING A-SUBSTITUTERD AMINES OR A-SUBSTITUTED AMINO ACIDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4134918-A | ENZYME INHIBITORS, ANTIBODY INHIBITORS | MERRELL TORAUDE ET COMPAGNIE (FR) | 1979-01-16 | — | — | US | disclosed |
| US-3957989-A | ADMINISTERING | RICHARDSON-MERRELL INC. (US) | 1976-05-18 | — | — | US | disclosed |
| US-3957988-A | Antiviral compositions containing bis-basic ketones of thioxanthene | RICHARDSON-MERRELL INC. (US) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237783-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | CDK4, CCNI, BCL2 | ALDH1A1 1614/4885ACHE 4763/4885KMT2A 2931/4885 |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | CDK4, CCNI, BCL2 | ALDH1A1 1614/4885ACHE 4763/4885KMT2A 2931/4885 |
| US-20160200670-A1 | RADIOPAQUE MONOMERS, POLYMERS, MICROSPHERES, AND METHODS RELATED THERETO | CD68, MVD, RAD54L | ALDH1A1 2345/4885ACHE 3901/4885KMT2A 1665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.