Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9210920 | 0.87 | ALOX5 (0.52) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9226271 | 0.87 | ALOX5 (0.52) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9226267 | 0.87 | ALOX5 (0.52) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9228641 | 0.86 | ADAM17 (0.40) | ALOX5ADAM17HTR2CSLC6A4HTR2B | |
| SCHEMBL9254867 | 0.86 | ALOX5 (0.54) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9226911 | 0.85 | ALOX5 (0.49) | ALOX5 | |
| SCHEMBL9218747 | 0.83 | ALOX5 (0.57) | ALOX5ADAM17 | |
| SCHEMBL9227946 | 0.83 | ALOX5 (0.57) | ALOX5ADAM17 | |
| SCHEMBL9218329 | 0.81 | ALOX5 (0.39) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9227917 | 0.79 | CCR2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5403859-A | PHENYLENE-CYCLIC ETHER COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-04 | — | — | US | disclosed |
| EP-0375404-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-02-09 | — | — | EP | disclosed |
| US-5234950-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, antiarthritic | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-10 | — | — | US | disclosed |
| US-5098930-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-24 | — | — | US | disclosed |