Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9224852 | 0.99 | NAMPT (0.44) | NAMPTGPBAR1ALDH1A1POLBCDK8 | |
| Hydrochloric Acid SCHEMBL9227322 | 0.83 | RAB9A (0.43) | NAMPTALDH1A1POLBSMN1; SMN2PTGS1 | |
| SCHEMBL9220315 | 0.83 | RXFP1 (0.57) | NAMPTALDH1A1CDK8PTGS1 | |
| Hydrochloric Acid SCHEMBL9229016 | 0.82 | RXFP1 (0.56) | NAMPTALDH1A1CDK8BRAFPTGS1 | |
| SCHEMBL9228293 | 0.77 | MEN1 (0.58) | NAMPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL9226881 | 0.76 | RXFP1 (0.53) | ALDH1A1PTGS1 | |
| Hydrochloric Acid SCHEMBL9220369 | 0.76 | NAMPT (0.55) | NAMPTALDH1A1BRAFPTGS1 | |
| Hydrochloric Acid SCHEMBL9225483 | 0.76 | MEN1 (0.57) | NAMPTALDH1A1POLBKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9224855 | 0.75 | RXFP1 (0.52) | ALDH1A1PTGS1 | |
| SCHEMBL9221688 | 0.75 | NR1H4 (0.49) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5397798-A | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1995-03-14 | — | — | US | claimed |
| EP-0491525-A1 | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1992-06-24 | — | — | EP | claimed |
| US-5397798-A | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1995-03-14 | — | — | US | disclosed |
| EP-0491525-A1 | Benzamide and sulfonamide hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1992-06-24 | — | — | EP | disclosed |